- Kauffman, California
- Draper Kauffman (1911–1979) Rear Admiral, US Navy
- Elizabeth Bush, born Kauffman
- Ewing Marion Kauffman
- George B. Kauffman, (born 1930) American chemist
- Louis Kauffman, American mathematician
- Marta Kauffman, TV producer and writer
- Matthew Kauffman, journalist
- Scott Kauffman, businessman
- Stuart (Alan) Kauffman, US theoretical biologist and complex systems researcher
- USS Kauffman (FFG-59)
- Kauffman's Distillery Covered Bridge
- Kauffman Stadium, named after Ewing Kauffman
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