Regular Cast
- Susan Saint James as Katherine Elizabeth Ann "Kate" (née Hanlan) McArdle
- Jane Curtin as Allison Julia Charlotte "Allie" (née Adams) Lowell (Barsky during the final season when she remarried)
- Ari Meyers as Emma McArdle, Kate's daughter. Meyers left the show a few episodes into the fifth season to attend Yale University (although her name remained in the opening credits to the end of the season); she returned for the season-ending 100th episode retrospective.
- Frederick Koehler as Charles "Chip" Lowell, Allie's son
- Allison Smith as Jennie Lowell, Allie's daughter
- Gregory Salata as Ted Bartelo, a plumber whom Kate gets involved with during the second season. The two break up in the season two finale. Ted returns for the fifth season, with he and Kate attempting to rekindle their relationship; by the end of this season, he is gone again.
- Sam Freed was featured as three different characters during the series. In the first season he played a married candidate for office named Johnathan Conti who flirts with Allie. At the end of season three he played Keith in the episode "Late Bloomers", which was a backdoor pilot for a proposed spinoff which would have starred Lindsay Wagner. In the final seasons, he was best known as Bob Barsky, the boyfriend and later husband of Allie.
- Peter Onorati as Lou Carello, the superintendent in Kate and Allie's new building, who appears in season six. He tries unsuccessfully to win Kate's affections.
Paul Hecht had a recurring role as Allie's ex-husband Charles. Wendie Malick, best known for her role in Just Shoot Me!, had one of her earliest roles as Charles' new wife Claire.
Read more about this topic: Kate & Allie
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