Karl Hoffmann may refer to:
- Karl Hoffmann (Swiss politician) (1820–1895), declined election to the Swiss Federal Council in 1881
- Karl Hoffmann (naturalist) (1823–1859), German physician and naturalist
- Karl Hoffmann (linguist) (1915–1996), German linguist
- Karl W. Hofmann (born 1961), former United States Ambassador to Togo