Karen may refer to:
- Karen people, an ethnic group in Burma and Thailand
- Karen languages, spoken by the Karen people
- Karen (name), a given name (and list of people with the name)
- Karen (1964 TV series), an NBC sitcom starring Debbie Watson
- Karen (1975 TV series), an ABC sitcom starring Karen Valentine
- Karen, Kenya, a suburb of Nairobi
- Hualien, Taiwan or Karen
- KAREN or Kiwi Advanced Research and Education Network
- House of Karen, a historical feudal family of Tabaristan, Iran
- Karen, a character in Mermaid Melody Pichi Pichi Pitch media
- Karen, Plankton's "computer" W.I.F.E. on the animated TV series, SpongeBob SquarePants