Characters in Kalki
- The five Perfect Masters
- Kalki, formerly James J. Kelly – ex-US Army chemical-warfare chemist and purported 10th reincarnation of the god Vishnu. Eventual last human survivor.
- Lakshmi, formerly Doris Pannicker – nuclear physicist and reincarnation of Vishnu's wife
- Dr. Giles Lowell (also CIA agent Dr. Ashok in disguise) – medical doctor. Avatar of Ravana.
- Geraldine O'Connor – biochemist and geneticist.
- Theodora Hecht Ottinger (Teddy) – engineer, aviatrix and the novel's narrator.
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