Synthetic Model of Allosteric Effects
Other bipyridyls and biphenyls were designed in the 1980s as synthetic models of allosteric effects shown below. One involved two identical and mechanically coupled binding sites and it showed positive cooperativity in binding of covalent mercury compounds. Rotors are still the most frequent chemical models for allosteric effects, and are present in many of the molecular machines pursued in other laboratories today.
Read more about this topic: Julius Rebek
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“In every philosophical school, three thinkers succeed one another in the following way: the first produces out of himself the sap and seed, the second draws it out into threads and spins a synthetic web, and the third waits in this web for the sacrificial victims that are caught in it—and tries to live off philosophy.”
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—David Hume (1711–1776)