Synthetic Model of Allosteric Effects
Other bipyridyls and biphenyls were designed in the 1980s as synthetic models of allosteric effects shown below. One involved two identical and mechanically coupled binding sites and it showed positive cooperativity in binding of covalent mercury compounds. Rotors are still the most frequent chemical models for allosteric effects, and are present in many of the molecular machines pursued in other laboratories today.
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