Molecular Recognition
Efforts in molecular recognition in the 1980s, led to cleft-like shapes for recognition of ions and especially nonionic targets. Using derivatives of Kemp’s triacid, Rebek arranged functional groups that “converged” to create a recognition site. Shown above is a bisimide that chelates adenine in water. Versions with carboxyl groups became widely used elsewhere as models for metalloenzymes (the XDK structures) and in Rebek’s laboratory to probe stereoelectronic effects.
Read more about this topic: Julius Rebek
Famous quotes containing the word recognition:
“Work expands so as to fill the time available for its completion. General recognition of this fact is shown in the proverbial phrase “It is the busiest man who has time to spare.””
—C. Northcote Parkinson (1909–1993)