Jughead may refer to:
- Fictional character
- Jug Head, Canadian nickname for the Kool-Aid Man
- Jughead, spelled "Jughaid", character in the newspaper comic Barney Google and Snuffy Smith
- Jughead Jones, Archie Comics character
- Music
- John Jughead, the pseudonym of Screeching Weasel guitarist John Pierson
- Jughead (band), a progressive pop side project of Ty Tabor in 2002
- "Jughead", a song on Prince's 1991 album Diamonds and Pearls
- Object or process
- Jughead, nickname for a version of the 1954 Mark 16 nuclear bomb
- Jughead (search engine), which worked under the Gopher protocol
- Onscreen
- "Jughead" (Lost), 2009 episode in the fifth season of the American television series Lost