Meyers officially joined the cast of MADtv in 2002, as a featured performer for the eighth season. He would fill in the spot of the Spishak Spokesperson that David Herman and Pat Kilbane previously owned. Meyers was also known for his celebrity impersonations, including Anna Nicole Smith's son, Daniel, various members of 'N Sync, rapper Eminem, and actor/writer Owen Wilson.
Meyers's appearances on MADtv on FOX aired directly opposite his brother Seth's appearances on Saturday Night Live on NBC. This was referenced on a season 28 episode of Saturday Night Live in which Seth appears on Weekend Update to talk to his father and tells him to turn off MADtv and pay attention to him.
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