John Keane may refer to:
- John Fryer Thomas Keane (1854–1937), British adventurer
- John J. Keane (bishop) (1839–1918), former archbishop of Dubuque, Iowa
- John Keane (artist) (born 1954), British artist
- John Keane (political theorist) (born 1949), Australian-born British political theorist
- John Keane (hurler) (1917–1975), Irish sportsman
- Jack Keane (hurler) (born 1895), Irish hurler for the Limerick senior team
- Sir John Keane, 1st Baronet (1757–1829), MP for Youghal
- John Keane, 1st Baron Keane (1781–1844), Major General, son of the above
- Sir John Keane, 5th Baronet (1873–1956), member of the first Irish government's Senate and a director of the Bank of Ireland
- John Keane (record producer), music producer and founder of the John Keane recording studio
- Jack Keane (John Keane, born 1943), former Vice Chief of Staff of the US Army
- John B. Keane (1928–2002), Irish playwright, novelist and essayist
- John E. Keane, British film and television composer
- John F. Keane, U.S. Ambassador to Paraguay, 2003–2005
- John J. Keane, Irish Fianna Fáil politician from Galway
- John M. Keane, American songwriter and musician who used to be a member of a pop musical group the Keane Brothers
- Jack Keane (video game), a 2007 video game by Deck13 Interactive
- John Keane (Gaelic footballer), Gaelic football player for Westmeath GAA
- Johnny Keane (1911–1967), American baseball player
- John B. Keane (architect) (died 1859), Irish architect