John Creighton may refer to:
- John Oliver Creighton, American astronaut
- John W. Creighton, Jr., American businessman
- John Creighton, 1st Earl Erne, Irish peer
- Lieutenant John Creighton, American Naval officer involved in the Little Belt Affair in 1811
- John Creighton (judge) (1721–1807), a lawyer and judge in Nova Scotia
- John Creighton (Nova Scotia politician) (1794–1878), a lawyer and politician in Nova Scotia, Canada
- John A. Creighton, businessman in Omaha, Nebraska