Scientists and Academics
- James Smith (educator), Scottish principal of Edinburgh University, 1732–1736
- James Edward Smith (1759–1828), English botanist and founder of the Linnean Society
- James George Smith (1819–1849), American founder of Beta Theta Pi, a prominent college fraternity
- James K. A. Smith (born 1970), Canadian-born Associate Professor of Philosophy at Calvin College
- James Monroe Smith (1888–1949), President of Louisiana State University, 1930–1939
- J.L.B. Smith (James Leonard Brierley Smith, 1897–1968), South African ichthyologist
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