Schmalhausen's Law
Schmalhausen's Law is a general principle that a population living at the boundary of its tolerance, in extreme or unusual conditions with regard to any aspect of its existence will be more vulnerable to small differences in any other aspect. Therefore the variance of data is not simply noise interfering with the detection of so-called "main effects", but also an indicator of stressful conditions leading to greater vulnerability.
Read more about this topic: Ivan Ivanovich Schmalhausen
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—Alexander Herzen (1812–1870)