Isley may refer to:
- Ernie Isley (born 1952), American musician and member of the The Isley Brothers
- Ernie Isley (Alberta politician), Canadian politician
- Marvin Isley (1953-2010), American musician and member of the The Isley Brothers
- Pamela Isley, the fictional DC Comics supervillain known as Poison Ivy
- O'Kelly Isley, Jr. (1937-1986), American musician and member of the The Isley Brothers
- Ronald Isley (born 1941), American musician and member of the The Isley Brothers
- Rudolph Isley (born 1939), American musician and member of the The Isley Brothers
- Vernon Isley (1942-1955), American musician and member of the The Isley Brothers
| This page or section lists people with the surname Isley. If an internal link intending to refer to a specific person led you to this page, you may wish to change that link by adding the person's given name(s) to the link. |