Computing
- International Information Systems Security Certification Consortium also known as (ISC)2 or (ISC)²
- Initiative for Software Choice, a group of software vendors
- Interactive Systems Corporation, a (defunct) Unix vendor
- Internet Storm Center, a program run by the SANS Institute that monitors the level of malicious activity on the internet
- International Supercomputing Conference, a yearly conference on Supercomputing which has been held in Europe
- Internet Systems Consortium, an organization that develops Internet software
- ISC license, a free software license introduced by the Internet Systems Consortium
Read more about this topic: ISC