ISB is an acronym for each of the following:
In automotive technology:
- The ISB Engine/Interact System B; A variant of the Cummins B Series engine engine used in Dodge trucks.
In music:
- The International Staff Band of the Salvation Army
- Incredible String Band, a British musical group of the late 1960s
- The International Submarine Band, a 1960s country-rock group featuring Gram Parsons
- International Society of Bassists, an international society dedicated to the double bass
In education:
- International School of Brussels, an international school located in Brussels, Belgium.
- Indian School of Business, a business school located in Hyderabad, India.
- International School of Beaverton, an international school located in Aloha, Oregon, USA.
- International School of Boston, an international school located in Cambridge, Massachusetts, United States of America.
- International School Bangkok, an international school located in Nonthaburi, Thailand; the school used to be located in Bangkok.
- International School Basel, an international school located in Basel, Switzerland.
- International School of Beijing, an international school located in Beijing, China.
- Institute for Systems Biology, a non-profit research institute dedicated to the study and application of systems biology.
- International School of Bergen, an international school located in Bergen, Norway.
- International School of Broward, an international school located in Hollywood, Florida
- International School of Belgrade, an international school located in Belgrade, Serbia.
In science:
- International Society of Biomechanics
In Islam:
- Islamic Society of Boston, a Muslim community center and mosque based in Boston, Massachusetts, United States of America
- Islamic Society of Baltimore, a tax exempt, non-profit religious organization registered in the state of Maryland, United States of America
- Islamic Society of Britain, a national voluntary organisation
Generally:
- independent sideband, a radio modulation mode used in some AM radio transmissions
- In-store bakery, a section of a shop or store which bakes various bread and cake products
- Invest to Save Budget, UK government scheme launched in 1998-99 "to support projects intended to foster changes in departments' methods of working so as to promote successful innovation and deliver better public services"
- Islamabad International Airport (IATA code "ISB"), also known as Chaklala Airbase, an airport located in Rawalpindi, Pakistan
- Infrastructure Support Business, Includes all businesses related to the building and operation of social infrastructure.
In movies:
- Imperial Security Bureau, a fictional organization in the Star Wars universe