Organizations
- Illinois Railway
- Indian Railways, the state-owned railway company of India
- Industrial relations (labor relations)
- Ingersoll Rand (NYSE trading symbol IR)
- Integrated Resort, a euphemism for a casino in Singapore
- Internal Revenue Service, the United States government agency that collects taxes and enforces the internal revenue laws
- International Rectifier, a manufacturer of power semiconductors
- International Rescue Corps, an organization inspired by the Thunderbirds TV series
- Iran Air (IATA airline code IR)
- Iarnród Éireann (Irish Rail), the national passenger and freight railway system of the Republic of Ireland
- Islamic Relief
- Israel Railways, the state-owned railway company of Israel
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