Interactions
IQGAP1 is a node intersected by many signaling pathways. As such it has many binding partners, many of which have essential roles in control of the cell cycle and actin cytoskeleton.
IQGAP1 has been shown to interact with:
- Calmodulin 1,
- CDC42,
- CDH1,
- CLIP1,
- PRKACA,
- RAC1, and
- S100B.
- Actin – cytoskeletal structure
- ARF6
- APC
- Beta-catenin–cell adhesion and and WNT signaling: transcription
- B-raf – MAPK pathway
- CD44
- Erk1/2 – MAPK pathway, cell cycle control, proliferation
- Mek ½ -- MAPK pathway, cell cycle control, proliferation
- Src
- PTPmu (PTPRM)
- complete list at
Read more about this topic: IQGAP1
Famous quotes containing the word interactions:
“In our interactions with people, a benevolent hypocrisy is frequently required—acting as though we do not see through the motives of their actions.”
—Friedrich Nietzsche (1844–1900)
“In child rearing it would unquestionably be easier if a child were to do something because we say so. The authoritarian method does expedite things, but it does not produce independent functioning. If a child has not mastered the underlying principles of human interactions and merely conforms out of coercion or conditioning, he has no tools to use, no resources to apply in the next situation that confronts him.”
—Elaine Heffner (20th century)
“The exercise of power is determined by thousands of interactions between the world of the powerful and that of the powerless, all the more so because these worlds are never divided by a sharp line: everyone has a small part of himself in both.”
—Václav Havel (b. 1936)