Disorder Prediction Software
There are many computational methods that exploit sequence information to predict whether a protein is disordered. Notable examples of such software include IUPRED and Disopred. Different software may use different definitions of disorder. Since the methods above use different definitions of disorder and they were trained on different datasets, it is difficult to estimate their relative accuracy. Disorder prediction category is a part of biannual CASP experiment that is designed to test methods according accuracy in finding regions with missing 3D structure (marked in PDB files as REMARK465).
Read more about this topic: Intrinsically Unstructured Proteins
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