Intrinsic Factor - Model Organisms

Model Organisms

Gif knockout mouse phenotype
Characteristic Phenotype
Homozygote viability Normal
Homozygous Fertility Abnormal
General Observations Abnormal
Body weight Normal
Anxiety Normal
Neurological assessment Normal
Grip strength Normal
Hot plate Normal
Dysmorphology Normal
Indirect calorimetry Normal
Glucose tolerance test Normal
Auditory brainstem response Normal
DEXA Normal
Radiography Normal
Body temperature Normal
Eye morphology Normal
Clinical chemistry Normal
Plasma immunoglobulins Normal
Haematology Normal
Peripheral blood lymphocytes Normal
Micronucleus test Normal
Heart weight Normal
Tail epidermis wholemount Normal
Skin Histopathology Normal
Brain histopathology Normal
MicroCT & Quantitative Faxitron Normal
Salmonella infection Abnormal
Citrobacter infection Abnormal
All tests and analysis from

Model organisms have been used in the study of intrinsic factor function. A conditional knockout mouse line, called Giftm1a(KOMP)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty seven tests were carried out on mutant mice and four significant abnormalities were observed. Homozygous mutant males displayed increased aggression towards their pups and therefore had reduced fecundity. Mutants of both sex had increased susceptibility to infection with both Citrobacter and Salmonella.

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