Etiologies
Common causes include infection, or reaction to medication (such as an analgesic or antibiotics such as Methicillin (Meticillin). Reaction to medications causes 71% to 92% of cases.
This disease is also caused by other diseases and toxins that do damage to the kidney. Both acute and chronic tubulointerstitial nephritis can be caused by a bacterial infection in the kidneys, known as pyelonephritis. The most common cause is by an allergic reaction to a drug. The drugs that are known to cause this sort of reaction are antibiotics such as penicillin and cephalexin, and nonsteroidal anti-inflammatory drugs, such as aspirin, as well as rifampin, sulfa drugs, quinolones, diuretics, allopurinol, and phenytoin. The time between exposure to the drug and the development of acute tubulointerstitial nephritis can be anywhere from 5 days to 5 months (fenoprofen induced).
Read more about this topic: Interstitial Nephritis