Interneuron - Interneurons in The Central Nervous System

Interneurons in The Central Nervous System

When contrasted with the peripheral nervous system (PNS), the neurons of the central nervous system (CNS), including the brain, are all interneurons. However, in the CNS, the term interneuron is used for small, locally projecting neurons (in contrast to larger projection neurons with long-distance connections). CNS interneurons are typically inhibitory, and use the neurotransmitter GABA or glycine. However, excitatory interneurons using glutamate also exist, as do interneurons releasing neuromodulators like acetylcholine.

In 2008, a nomenclature for the features of GABAergic cortical interneurons was proposed, called Petilla terminology.

Inhibitory interneurons are thought to play an important role in the generation of neural oscillations.

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