Criticism
ISAT was criticised on a number of factors, many related to the randomization of the patient population. The patient population was on average younger, and the majority had aneurysms under 10 mm and in anterior circulation. The randomized patient population in the ISAT was younger on average than the population of subarachnoid hemorrhage patients in the U.S. and Japan. In response to these criticisms a facility that participated in ISAT compared the clinical outcomes of their patients that were not selected for the study to those that were. They reported finding outcomes similar to the ISAT.
Read more about this topic: International Subarachnoid Aneurysm Trial
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