Target Cells
While neutrophil granulocytes are the primary target cells of IL-8, there is a relative wide range of cells (endothelial cells, macrophages, mast cells, and keratinocytes) responding to this chemokine, too. The chemoattractant activity of IL-8 in similar concentrations to vertebrates was proven in Tetrahymena pyriformis, which refers to a phylogenetically well-conserved structure and function in the case of this chemokine.
Read more about this topic: Interleukin 8
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