Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a protein that in humans is encoded by the IGF1 gene. IGF-1 has also been referred to as a "sulfation factor" and its effects were termed "nonsuppressible insulin-like activity" (NSILA) in the 1970s.
IGF-1 is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. A synthetic analog of IGF-1, mecasermin is used for the treatment of growth failure.
IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 has a molecular weight of 17,066 daltons.
Read more about Insulin-like Growth Factor 1: Synthesis and Circulation, Mechanism of Action, Receptors, Related Growth Factors, Contribution To Ageing, Factors Influencing The Levels in The Circulation, Neuropathy, Dwarfism, IGF-I and Cancer, Use As A Diagnostic Test, As A Therapeutic Agent, Interactions
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