Insulin-degrading Enzyme - Model Organisms

Model Organisms

Ide knockout mouse phenotype
Characteristic Phenotype
Homozygote viability Normal
Fertility Normal
General Observations Abnormal
Body weight Normal
Anxiety Normal
Neurological assessment Normal
Grip strength Normal
Hot plate Normal
Dysmorphology Normal
Indirect calorimetry Normal
Glucose tolerance test Normal
Auditory brainstem response Normal
DEXA Normal
Radiography Normal
Body temperature Normal
Eye morphology Normal
Clinical chemistry Normal
Haematology Normal
Peripheral blood lymphocytes Abnormal
Micronucleus test Normal
Heart weight Normal
Salmonella infection Normal
Citrobacter infection Normal
All tests and analysis from

Model organisms have been used in the study of IDE function. A conditional knockout mouse line, called Idetm1a(EUCOMM)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty three tests were carried out on mutant mice and two significant abnormalities were observed. Homozygous mutant animals displayed abnormal drinking behavior, and males also had an increased NK cell number.

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