The immunoglobulin heavy chain (IgH) is the large polypeptide subunit of an antibody (immunoglobulin).
A typical antibody is composed of two immunoglobulin (Ig) heavy chains and two Ig light chains. Several different types of heavy chain exist that define the class or isotype of an antibody. These heavy chain types vary between different animals. All heavy chains contain a series of immunoglobulin domains, usually with one variable domain (VH) that is important for binding antigen and several constant domains (CH1, CH2, etc.).
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Famous quotes containing the words heavy and/or chain:
“Slow, slow, fresh fount, keep time with my salt tears;
Yet slower yet, oh faintly gentle springs:
List to the heavy part the music bears,
“Woe weeps out her division when she sings.”
Droop herbs and flowers;
Fall grief in showers;
“Our beauties are not ours”:
Oh, I could still,
Like melting snow upon some craggy hill,
Drop, drop, drop, drop,
Since nature’s pride is, now, a withered daffodil.”
—Ben Jonson (1572–1637)
“Nae living man I’ll love again,
Since that my lovely knight is slain.
Wi ae lock of his yellow hair
I’ll chain my heart for evermair.”
—Unknown. The Lament of the Border Widow (l. 25–28)