Cytokines Responsible For Class Switching
T cell cytokines are responsible for class switching in mouse (Table 1) and human (Table 2). These cytokines may have suppressive effect on production of IgM.
T cells | Cytokines | Immunoglobulin classes | |||||
---|---|---|---|---|---|---|---|
IgG1 | IgG2a | IgG2b | IgG3 | IgA | IgE | ||
Th2 | IL-4 | ↑ | ↓ | ↓ | ↓ | ↓ | ↑ |
IL-5 | ↑ | ||||||
Th1 | IFNγ | ↓ | ↑ | ↓ | ↓ | ↓ | ↓ |
Treg | TGFβ | ↑ | ↓ | ↑ |
T cells | Cytokines | Immunoglobulin classes | |||||
---|---|---|---|---|---|---|---|
IgG1 | IgG2 | IgG3 | IgG4 | IgA | IgE | ||
Th2 | IL-4 | ↑ | ↑ | ||||
IL-5 | ↑ | ||||||
Th1 | IFNγ | ||||||
Treg | TGFβ | ↑ |
Read more about this topic: Immunoglobulin Class Switching
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