Immunoglobulin Class Switching - Cytokines Responsible For Class Switching

Cytokines Responsible For Class Switching

T cell cytokines are responsible for class switching in mouse (Table 1) and human (Table 2). These cytokines may have suppressive effect on production of IgM.

Table 1. Class switching in mouse
T cells Cytokines Immunoglobulin classes
IgG1 IgG2a IgG2b IgG3 IgA IgE
Th2 IL-4 ↑ ↓ ↓ ↓ ↓ ↑
IL-5 ↑
Th1 IFNγ ↓ ↑ ↓ ↓ ↓ ↓
Treg TGFβ ↑ ↓ ↑
Table 2. Class switching in human
T cells Cytokines Immunoglobulin classes
IgG1 IgG2 IgG3 IgG4 IgA IgE
Th2 IL-4 ↑ ↑
IL-5 ↑
Th1 IFNγ
Treg TGFβ ↑

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