Ongoing Research
The vaccine tested in the phase II clinical trial in India did not proceed further because it produced antibody titers of 50 ng/mL for at least 3 months duration in only 60% of women in the trial. Ongoing research in hCG birth control vaccines has focused on improving immunogenicity. A vaccine in which the beta subunit of hCG is fused to the B subunit of Escherichia coli heat-labile enterotoxin has been effective in laboratory mice. It has been approved by the Indian National Review Committee on Genetic Manipulation and is being produced for pre-clinical toxicology testing. If it is determined to be safe, it is planned for clinical trials.
Read more about this topic: Immunocontraception, Gamete Outcome, Human Chorionic Gonadotropin
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