IL1A

IL1A

Identifiers Symbols IL1A; IL-1A; IL1; IL1-ALPHA; IL1F1 External IDs OMIM: 147760 MGI: 96542 HomoloGene: 480 GeneCards: IL1A Gene

Gene Ontology
Molecular function	• cytokine activity • interleukin-1 receptor binding • copper ion binding • protein binding
Cellular component	• extracellular region • extracellular space • cytosol • cell surface
Biological process	• fever generation • response to hypoxia • apoptotic process • anti-apoptosis • inflammatory response • immune response • cell proliferation • negative regulation of cell proliferation • response to ozone • response to organic nitrogen • response to gamma radiation • positive regulation vascular endothelial growth factor production • positive regulation of steroid biosynthetic process • response to organic cyclic compound • cytokine-mediated signaling pathway • keratinization • response to lipopolysaccharide • positive regulation of interleukin-6 production • response to L-ascorbic acid • cellular response to heat • wound healing • positive regulation of I-kappaB kinase/NF-kappaB cascade • positive regulation of interleukin-2 biosynthetic process • positive regulation of angiogenesis • positive regulation of mitosis • positive regulation of transcription from RNA polymerase II promoter • positive regulation of JNK cascade • response to copper ion • positive regulation of cytokine secretion • positive regulation of cell division • regulation of sensory perception of pain • positive regulation of ERK1 and ERK2 cascade
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3552 16175 Ensembl ENSG00000115008 ENSMUSG00000027399 UniProt P01583 P01582 RefSeq (mRNA) NM_000575.3 NM_010554.4 RefSeq (protein) NP_000566.3 NP_034684.2 Location (UCSC) Chr 2:
113.53 – 113.54 Mb Chr 2:
129.3 – 129.31 Mb PubMed search

Interleukin-1 alpha (IL-1α) is a protein of the interleukin-1 family that in humans is encoded by the IL1A gene. In general, Interleukin 1 is responsible for the production of inflammation, as well as the promotion of fever and sepsis. IL-1α inhibitors are being developed to interrupt those processes and treat diseases.

IL-1α is produced mainly by activated macrophages, as well as neutrophils, epithelial cells, and endothelial cells. It possesses metabolic, physiological, haematopoietic activities, and plays one of the central roles in the regulation of the immune responses. It binds to the interleukin-1 receptor. It is on the pathway that activates tumor necrosis factor-alpha.

IL-1α is a cytokine of the interleukin-1 family.