IIC may refer to
- I²C, Inter-Integrated Circuit, a serial computer bus
- International Institute for Conservation, the global membership organisation for conservation professionals.
- Investigator In Charge, a person who is responsible for all activities of an investigation team of an accident or incident of an aircraft.
- India International Centre, New Delhi, India.
- Israeli Intelligence Community
- International Review of Intellectual Property and Competition Law, a publication in intellectual property law
- IT Infrastructure Coordinator, one who manages IT development for specific departments within a company. Responsible for prioritizing requests from internal and external business users. Works with System Engineer and Developers.
- Istituto Italiano di Cultura, an Italian Cultural Institute of the Italian Ministry of Foreign Affairs
- Impact insulation class, a method of determining how effective a floor structure is to footfall noise
- Apple IIc, a personal computer introduced by Apple Computer in April 1984
- Instituto de Ingeniería del Conocimiento The Knowledge Engineering Institute (CII) is a Spanish research, development and innovation center located on the campus of Universidad Autonoma de Madrid (UAM)
- Islamic Information Center (IIC), a Washington DC based Islamic advocacy group.