Hypostatic or Hypostasis (from the Ancient Greek ὑπόστᾰσις) may refer to:
- Hypostatic abstraction (mathematics and logic)
- Hypostasis (linguistics), personification of entities
- Hypostatic gene, as a result of epistasis
- Hypostasis (philosophy and religion), the essence, or underlying reality
- Hypostasis (medicine), Livor mortis
- Hypostasis (personality), a pschological model, or theory, of personality masks
- Hypostatic union, Christian concept
- Holding current (electronics) known as the hypostatic
- Sediment in a liquid, including:
- Sediment#Dregs