Hypervariable Region - Antibodies

Antibodies

Further information: Complementarity determining region and Framework region

In antibodies, hypervariable regions form the antigen-binding site and are found on both light and heavy chains. They also contribute to the specificity of each antibody. In a variable region, the 3 H_V segments of each heavy or light chain fold together at the N-terminus to form an antigen binding pocket.