Causes
Since hyperinsulinemia and obesity are so closely linked it is hard to determine whether hyperinsulinemia causes obesity or obesity causes hyperinsulinemia, or both. Obese people have an excess of adipose tissue. Adipose tissue is known to secrete various metabolites, hormones and cytokines that may play a role in causing hyperinsulinemia. Specifically cytokines secreted by adipose tissue directly effect the insulin signalling cascade, and thus insulin secretion. Adiponectins are cytokines that are inversely related to percent body fat; that is people with a low body fat will have higher concentrations of adiponectins where as people with high body fat will have lower concentrations of adiponectincs. Weyer "et al,." (2011) have discovered that hyperinsulinemia can be due in large part to low adiponectin concentrations in obese people.
- Neoplasm, pancreatic cancer, PCOS, Trans Fats
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