Asymmetric Hydroformylation
Hydroformylation of prochiral alkenes creates new stereocenters. Using chiral phosphine ligands, the hydroformylation can be tailored to favor one enantiomer. Thus, for example, Dexibuprofen, the (+)-(s)-enantiomer of Ibuprofen, can be produced by enantioselective hydroformylation followed by oxidation.
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