History
During 1986, Dharam Ablashi, Syed Zaki Salahuddin, and Robert Gallo cultivated peripheral blood mononuclear cells from patients with AIDS and lymphoproliferative illnesses. When they did, they found short-lived, large, refractile cells that frequently contained intranuclear and/or intracytoplasmic inclusion bodies. Electron microscopy revealed a novel virus that they named human B-lymphotrophic virus (HBLV).
Shortly after its discovery, Ablashi et al. described five cell lines that can be infected by the newly discovered HBLV. They published that HSB-2, a particular T-cell line, was highly susceptible to infection. This pioneering research concluded by suggesting that the virus name be changed from HBLV to HHV-6, in accord with the published provisional classification of herpes viruses.
Years later, HHV-6 was divided into subtypes. Early research resulted in the description of two very similar, yet unique forms: variants HHV-6A and HHV-6B. This distinction first appeared in the literature during 1992. The separation was warranted because of their unique restriction endonuclease cleavage patterns, reactivities to monoclonal antibodies, and growth patterns in various cell lines.
HHV-6A includes several adult-derived strains and its disease spectrum is not well defined, although it is thought by some to be more neurovirulent. HHV-6B is commonly detected in children with roseola infantum, as it is the etiologic agent for this condition. Within these two viruses is a sequence homology of 95%.
In 2012, HHV-6A and HHV-6B were classified as distinct species.
Read more about this topic: Human Herpesvirus 6
Famous quotes containing the word history:
“Don’t you realize that this is a new empire? Why, folks, there’s never been anything like this since creation. Creation, huh, that took six days, this was done in one. History made in an hour. Why it’s a miracle out of the Old Testament!”
—Howard Estabrook (1884–1978)
“If usually the “present age” is no very long time, still, at our pleasure, or in the service of some such unity of meaning as the history of civilization, or the study of geology, may suggest, we may conceive the present as extending over many centuries, or over a hundred thousand years.”
—Josiah Royce (1855–1916)
“We don’t know when our name came into being or how some distant ancestor acquired it. We don’t understand our name at all, we don’t know its history and yet we bear it with exalted fidelity, we merge with it, we like it, we are ridiculously proud of it as if we had thought it up ourselves in a moment of brilliant inspiration.”
—Milan Kundera (b. 1929)