HSV may refer to:
- Herpes simplex virus
- HSV color space (hue, saturation, value)
- HSV (TV station) television station, the Melbourne station of Australia's Seven television network
- HSV-X1 Joint Venture, a commercial catamaran formerly leased by the United States Navy
- HSV-2 Swift, a non-commissioned catamaran leased by the United States Navy
- Holden Special Vehicles, the performance car partner of Australian automaker GM Holden Ltd
- Hamburger SV, a German football club in Hamburg
- HSV Handball, a German handball club in Hamburg
- Hannover 96 or Hannoverscher Sportverein (HSV) von 1896, a German football club in Hanover
- A common abbreviation for Huntsville, Alabama
- Huntsville International Airport's IATA code