HRE is a three-letter abbreviation which may represent any of the following:
- Harare International Airport (IATA airport code: HRE)
- Holy Roman Empire
- Holy Roman Emperor
- Hormone response element
- H're people (also spelled Hrê or Hre), an ethnic minority and language of Vietnam
- HRE, a level of the hardness of metallic materials on the Rockwell scale
- Hypo Real Estate, a German holding company