HOXC6

Identifiers Symbols HOXC6; CP25; HHO.C8; HOX3; HOX3C External IDs OMIM: 142972 MGI: 96197 HomoloGene: 19533 GeneCards: HOXC6 Gene

Gene Ontology
Molecular function	• sequence-specific DNA binding transcription factor activity • transcription corepressor activity • sequence-specific DNA binding
Cellular component	• nucleus
Biological process	• transcription, DNA-dependent • regulation of transcription from RNA polymerase II promoter • multicellular organismal development • anterior/posterior pattern specification • embryonic skeletal system development
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3223 15425 Ensembl ENSG00000197757 ENSMUSG00000001661 UniProt P09630 B2RUB8 RefSeq (mRNA) NM_004503 NM_010465 RefSeq (protein) NP_004494 NP_034595 Location (UCSC) Chr 12:
54.38 – 54.42 Mb Chr 15:
103 – 103.01 Mb PubMed search

Homeobox protein Hox-C6 is a protein that in humans is encoded by the HOXC6 gene.

This gene belongs to the homeobox family, members of which encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC6, is one of several HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Alternatively spliced transcript variants encoding different isoforms have been identified for HOXC6. Transcript variant two includes the shared exon, and transcript variant one includes only gene-specific exons.