Hormesis - History

History

German pharmacologist Hugo Schulz first described such a phenomenon in 1888 following his own observations that the growth of yeast could be stimulated by small doses of poisons. This was coupled with the work of German physician Rudolph Arndt, who studied animals given low doses of drugs, eventually giving rise to the Arndt-Schulz rule. Arndt's advocacy of homeopathy contributed to the rule's diminished credibility in the 1920s and 1930s. The term "hormesis" was coined and used for the first time in a scientific paper by C.M. Southam and J. Ehrlich in 1943 in the journal: Phytopathology, volume 33, pp. 517–541. Recently, Edward Calabrese has revived the hormesis theory through his research on peppermint plants.

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