Hop (protein)

Hop (protein)

Identifiers Symbols STIP1; HOP; IEF-SSP-3521; P60; STI1; STI1L External IDs OMIM: 605063 MGI: 109130 HomoloGene: 4965 GeneCards: STIP1 Gene

Gene Ontology
Molecular function	• protein binding
Cellular component	• nucleus • Golgi apparatus
Biological process	• response to stress • axon guidance
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 10963 20867 Ensembl ENSG00000168439 ENSMUSG00000024966 UniProt P31948 Q60864 RefSeq (mRNA) NM_006819.2 NM_016737.2 RefSeq (protein) NP_006810.1 NP_058017.1 Location (UCSC) Chr 11:
63.95 – 63.97 Mb Chr 19:
7.02 – 7.04 Mb PubMed search

Hop, occasionally written HOP, is an abbreviation for Hsp70-Hsp90 Organizing Protein. It functions as a co-chaperone which reversibly links together the protein chaperones Hsp70 and Hsp90.

Hop belongs to the large group of co-chaperones, which regulate and assist the major chaperones (mainly heat shock proteins). It is one of the best studied co-chaperones of the Hsp70/Hsp90-complex. It was first discovered in yeast and homologues were identified in human, mouse, rat, insects, plants, parasites, and virus. The family of these proteins is referred to as STI1 (stress inducible protein) and can be divided into yeast, plant, and animal STI1 (Hop).