Hom, HOM, or similar may refer to:
- Hom (musical instrument), a class of trumpet-like wind instruments, as used in pre-Columbian and traditional Maya music of Mesoamerica
- Hall of mirrors effect, in 3D computer graphics
- Hands On Miami, a volunteer community-service organization in Miami, Florida
- Head of Mission, a generic term used to refer to the head of a diplomatic representation
- Heart of Misery, a song by Finnish rock band The Rasmus
- Higher-order modulation, a type of digital modulation usually with an order of 4 or higher
- Holland (Amtrak station), a railway station in Michigan, USA (Amtrak station code HOM)
- Hom functor, as defined in the mathematical field of category theory, a functor or specialised type of morphism between small category sets
- HOm scale, a particular model railway scale or gauge
- Homer Airport in Homer, Alaska (IATA code HOM)
- House of Milan, American publisher of bondage magazines
- Armenian Relief Society, alternate acronym HOM, based on the Armenian name Հայ Օգնութիան Միութիւն