HLA A3-B7-DR15-DQ6
freq | Rank in | |||
ref. | Population | (%) | Pop. | |
Swiss | 9.1 | 1 | ||
Ireland | 8.6 | |||
Austria | 7.4 | 1 | ||
Northern Ireland | 6.5 | 1 | ||
Netherlands | 6.6 | |||
Belgium | 6.0 | 1 | ||
Swedish | 5.7 | 3 | ||
German | 5.7 | |||
Polish | 4.9 | |||
Romanian | 3.8 | |||
Armenia | 3.7 | |||
Portuguese | 3.4 | |||
British | 3.4 | |||
Czech | 3.1 | |||
Svans | 2.7 | |||
Albania | 2.7 | |||
Tuscan Italy | 2.7 | |||
Spanish | 2.6 | |||
Basque | 2.5 | |||
Italy | 1.6 | |||
Greek | 1.3 | |||
Bulgaria | 1.1 | |||
1 Cw*0702 (Europe) |
The gene-allele representation of the haplotype is:
HLA A*0301Cw*0702 : B*0702 : DRB1*1501 : DQA1*0102 : DQB1*0602
This is considered now the longest of the widely distributed ancestral haplotypes, its length is 4.8 million nucleotides and extends from TRIM27 gene . . . .The haplotype is nodal in Ireland but is also at high frequency in Switzerland, it has a subnode in the Pasiegos of northern Spain. There is some variance in the distribution of A3::DQ6 relative to A1::DQ2 in that there is more of a bias toward central and eastern Europe. Parts of the haplotype are spread into East Asia and even appear within the New world's indigeonous populations. DR15:DQ6 frequencies peak in central Asia, and it is suspect that this may be a point of Eurasian spread westward into Europe.
While there are some diseases associated with the haplotype, the frequency of association is less compared to A1::B8.
Read more about this topic: HLA B7-DR15-DQ6