HLA A3-B7-DR15-DQ6
| freq | Rank in | |||
| ref. | Population | (%) | Pop. | |
| Swiss | 9.1 | 1 | ||
| Ireland | 8.6 | |||
| Austria | 7.4 | 1 | ||
| Northern Ireland | 6.5 | 1 | ||
| Netherlands | 6.6 | |||
| Belgium | 6.0 | 1 | ||
| Swedish | 5.7 | 3 | ||
| German | 5.7 | |||
| Polish | 4.9 | |||
| Romanian | 3.8 | |||
| Armenia | 3.7 | |||
| Portuguese | 3.4 | |||
| British | 3.4 | |||
| Czech | 3.1 | |||
| Svans | 2.7 | |||
| Albania | 2.7 | |||
| Tuscan Italy | 2.7 | |||
| Spanish | 2.6 | |||
| Basque | 2.5 | |||
| Italy | 1.6 | |||
| Greek | 1.3 | |||
| Bulgaria | 1.1 | |||
| 1 Cw*0702 (Europe) | ||||
The gene-allele representation of the haplotype is:
HLA A*0301Cw*0702 : B*0702 : DRB1*1501 : DQA1*0102 : DQB1*0602
This is considered now the longest of the widely distributed ancestral haplotypes, its length is 4.8 million nucleotides and extends from TRIM27 gene . . . .The haplotype is nodal in Ireland but is also at high frequency in Switzerland, it has a subnode in the Pasiegos of northern Spain. There is some variance in the distribution of A3::DQ6 relative to A1::DQ2 in that there is more of a bias toward central and eastern Europe. Parts of the haplotype are spread into East Asia and even appear within the New world's indigeonous populations. DR15:DQ6 frequencies peak in central Asia, and it is suspect that this may be a point of Eurasian spread westward into Europe.
While there are some diseases associated with the haplotype, the frequency of association is less compared to A1::B8.
Read more about this topic: HLA B7-DR15-DQ6