Disease Associations
HLA B7-DR15-DQ6 was found to have an association with postmenopausal osteoporosis in a Greek population.
DR2 (15 or 16) -DQ6.2 has been found to associate with (idiopathic) narcolepsy-cataplexy Hypocretin ligand deficiency in the brain and cerebrospinal fluid is also link to narcolepsy-cataplexy. DR15-DQ6 also shows an association with factors (including a genetic factor on chromosome 12p12) involved in familial multiple sclerosis DR15-DQ6 is strongly associated with the development of choroidal neovascular lesions in presumed ocular histoplasmosis syndrome.
The DR15-DQ6 haplotype may afford some greater protection against the progression of HIV. However, the haplotype is a risk factor in cervical cancer.
Read more about this topic: HLA B7-DR15-DQ6
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