HLA-DQ8 - Serology

Serology

Serotype recognition of some DQB1*03 alleles
DQB1*	DQ8	DQ3	DQ7	Sample
allele	%	%	%	size (N)
*0302	66	23	4	6687
*0304	8	35	40	111
*0305	34	30		70
Red indicates the level of 'false' reaction in non-DQ8 serotypes
Alleles link-out to IMGT/HLA Databease at EBI

Select list of
**HLA DQB1*0302 frequencies**
		freq
ref.	Population	(%)
	Guatemala Mayans	48.1
	Mexico N.Leon Mestizos	22.5
	USA South Texas Hispanics	20.6
	Sweden	18.7
	Russia Siberia Negidal	18.6
	Russia Murmansk Saomi	18.5
	Jordan Amman	17.8
	Samoa	17.2
	England Caucasoid	16.4
	Finland	15.7
	France	14.5
	Japan Central	10.8
	Greece Crete	9.2
	Spain Basque Arratia Valley	6.7
	Algeria Oran	6.6
	China Beijing and Xian	6.1
	Ethiopia Amhara	5.6
	USA SE African American	4.9
	USA Alaska Yupik Natives	3.8
	India North Hindus	3.0
	Zimbabwe Harare Shona	2.2
	Russia Siberia Eskimos	0.9
	Rwanda Kigali Hutu and Tutsi	0.5
	PNG Eastern Highlands Goroka	0.0
	Tunisia Jerba Berber	0.0

Although false reaction with DQB1*0302 is low, the efficiency of the positive reaction is not good and there is a risk of false detection of DQB1*0305 which could create incompatibility. For disease diagnosis and confirmation, there is no known association of DQB1*0305 with either coeliac or autoimmune diabetes. Therefore it is prudent to use high resolution DQB1 typing for DQ8.