Haplotypes
| freq | ||
| ref. | Population | (%) |
| Chukotka Chukchi (Siberia) | 26.7 | |
| Chukotka Eskimos (Siberia) | 25.0 | |
| Koryaks (NE Kamchatka, Siberia) | 19.1 | |
| Polygus Evenks (Siberia) | 11.4 | |
| Khalkh (Ulaanbaatar, Mongolia) | 11.0 | |
| Negidal (Siberia) | 9.6 | |
| Kushun Buryat (Siberia) | 8.0 | |
| Tarialan Khoton (Mongolia) | 7.8 | |
| France Ceph | 6.0 | |
| Russia Tuva (2) | 6.0 | |
| Udegeys Gvaysugi (Siberia) | 4.8 | |
| Irkutsk Tofalar (Siberia ) | 4.7 | |
| Ulchi (Siberia) | 4.1 | |
| Belgian pop2 | 4.1 | |
| England Caucasoid | 4.0 | |
| Italy pop 2 | 2.8 | |
| Russia Tuva Todja | 2.3 | |
| China Ürümqi Kazak | 2.4 | |
| Sulamai Kets (Siberia) | 2.3 | |
| Russia Siberia Nganasan Dudinka | 2.1 | |
| NW Slavic Russia | 2.0 | |
| Japan Fukuoka | 1.2 | |
| Japan (2) | 1.1 |
DQ haplotypes of this serotype are formed between the cis-chromosomal genes of the DQA1 locus. This includes DQA1*0301, *0302, *0303, *0401, *0505, *0601.
There is a rather large degree of disequilibration about DQA1*0301 suggesting that this is one of the older and more established HLA DQB1* alleles in Eurasia. The intron structure of DQB1 suggest that DQB1*0301 DQB1*0302/*0303 split occurred before DQB1*0302/*0303, the distribution of *03 in Africa suggest that recombination DQA1*03:DQB1*0301 are primarily the result of recombination events that have occurred in Africa. A recent study of myasthenia gravis in Houston confirms the presence of A*0505:B*0301 in Nigeria. B1*0301 and A1*03 haplotypes are found at relatively high frequencies in SE Asia and Austronesia, also indicating that it is well established in the exo-African population.
Read more about this topic: HLA-DQ7