DQ4 and Disease
DQ4 is associated with:
- juvenile diabetic retinopathy
The DR8-DQ4 haplotype is associated with
- papillary thyroid carcinomas
- juvenile idiopathic arthritis via DR8 allele,
- chronic chlamydia infection,
- possibly pemphigus
DR4-DQ4(DRB1*0405:DQB1*0401) is associated with:
- autoimmune pancreatitis,
- juvenile type 1 diabetes,
- rheumatoid arthritis in Japanese.
The DQA1*0303:DQB1*04 haplotype is associated with:
- Crohn's disease in Japanese.
Other diseases mentioned are high altitude pulmonary edema, Vogt-Koyanagi-Harada syndrome (DRB1*0405, see above table for Japanese), HIV resistance in the US, and haemophilia A(anti-FVIII inhibitor response).
Read more about this topic: HLA-DQ4
Famous quotes containing the word disease:
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—Sarah Josepha Buell Hale 1788–1879, U.S. novelist, poet and women’s magazine editor. American Ladies Magazine, pp. 36-40 (December 1828)