HLA-DQ1 - Serotypes

Serotypes

Some DRB1* alleles and DQ5, DQ1, DQ6 recognition
DQB1*	DQ5	DQ1	DQ6	Sample
allele	%	%	%	size (N)
0501	69	20	2	5536
0502	48	24	15	919
0503	58	22	4	1327
0504	59	17	2	48
				.
	DQ6	DQ1	DQ5	N
0601	64	23		675
0602	67	30	1	5151
0603	62	23	2	2807
0604	59	27	2	1592
0605	76	13		358
0609	48	32	3	149

The serotyping efficiency of DQ1 recognition relative to DQ5 and DQ6 is listed below. Since DQ1 recognizes alpha, the DQ5 and DQ6 recognition are to beta chain. Meaning that DQ1 is corecognized with DQ5 and DQ6.

The table to the left shows some of the serotyping efficiencies. Efficient recognition of a genotyped allele approaches 100%. Compared to DQ2 serotyping of DQB1*0201 positive individuals (98%), the efficiency of DQ1 recognition is relatively low and error prone.

For this reason DQ1 serotyping is a poor method of typing for transplantation or disease association prediction or study. Nonetheless, it is still widely used and association purported in the literature.