| Ext. | Description | Used by |
|---|---|---|
| E | E language source code | E |
| E2D | 2-dimensional vector graphics file | Editor included in JFire |
| EAS | Extended file attributes | OS/2 |
| EAR | Enterprise archive | archive |
| EBA | Source code | Emergence BASIC |
| EBJ | Error-checking object file | Geoworks |
| EBQ | CITE standard electronic BQ exchange file | |
| EC | Error checking preprosessed Goc source code | Geoworks |
| EC | Source code | Ecere SDK |
| ECC | Error-checking file | dvdisaster |
| ECE | Escenic Contentng Engine dynamic page | Escenic |
| ECMS | Status document | ECMerge |
| ECMT | Template document / Session | ECMerge |
| ED5 | EDMICS | GCGW |
| EDA | Ensoniq ASR disk image | AWAVE |
| EDE | Ensoniq EPS disk image | AWAVE |
| EDF | European data format | Medical timeseries storage files |
| EDF | Exchequer Document Format | IRIS Software |
| EDF | Macrocom Online Kitchen-planer | |
| EDK | Ensoniq KT disk image | AWAVE |
| EDL | EDL | Premiere |
| EDQ | Ensoniq sq1,2/ks32 disk image | AWAVE |
| EDS | Ensoniq SQ80 disk image | AWAVE |
| EDT | Default settings | VAX Edt editor |
| EDT | Ensoniq TS disk image | AWAVE |
| EDT | External editors definitions | DN |
| EDV | Ensoniq VFX-SD disk image | AWAVE |
| EEB | Button bar for Equation Editor | WordPerfect for Win |
| EFA | Ensoniq ASR file | AWAVE |
| EFA | Encrypted File Archive | |
| EFE | Ensoniq EPS file | AWAVE |
| EFE | Ensoniq EPS instrument file | AWAVE |
| EFK | Ensoniq KT file | AWAVE |
| EFQ | Ensoniq SQ1/SQ2/KS32 file | AWAVE |
| EFS | Ensoniq SQ80 file | AWAVE |
| EFT | Ensoniq TS file | AWAVE |
| EFT | High resolution screen font | ChiWriter |
| EFV | Ensoniq VFX-SD file | AWAVE |
| EFX | Fax | Everex EFax |
| EGA | EGA display font | Ventura Publisher |
| EKA | Internal data files | Borland's Eureka |
| EL | ELISP source code file | Emacs lisp |
| ELB | Synergy/DE library | |
| ELC | Compiled ELISP code | Emacs lisp |
| ELFO | ElsterFormular | |
| ELI | Archive | ELI |
| ELT | Event list text file | Prosa |
| EMAKER | E language source code (maker) | E |
| EMD | ABT Extended MoDule | AWAVE |
| EMF | Microsoft Enhanced Metafile | |
| EML | Stationery Template | Outlook Express |
| EMU | Terminal emulation data | BITCOM |
| ENC | Encoded file - UUENCODEd file | Lotus 1-2-3 - uuexe515.exe |
| ENC | Music | Encore |
| END | Arrow-head definition file | CorelDRAW |
| ENFF | Extended Neutral File Format | |
| ENG | Dictionary engine | Sprint |
| ENG | English documentation | |
| ENG | Graphics file (charting) | EnerGraphics |
| ENV | Envelope or Environments | |
| ENV | Enveloper macro | WOPR |
| ENV | Environment file | WordPerfect for Win |
| EPA | Award BIOS splash screen | Award BIOS, XnView |
| EPD | Publication | Express Publisher |
| EPI | Document | Express Publisher |
| EPI | Encapsulated PostScript graphic file | |
| EPS | Encapsulated PostScript (Graphics format) | CorelDraw - PhotoStyler - PMView - Adobe Illustrator - Ventua Publisher |
| EPUB | Electronic Publication - (e-Reader format) | Okular (Linux) - Apple iBooks - Sony Reader - Adobe Digital Editions - Calibre (LMW) |
| EQN | Equation filE | WordPerfect for Win |
| ERD | Entity Relationship Diagram graphic file | Prosa |
| ERL | Erlang source code file | |
| ERM | Entity Relationship Diagram model file | Prosa |
| ERR | Compiler/linker error report | |
| ESH | Extended Shell batch file | |
| ETH | Document | Ethnograph 3 |
| ETF | Encrypted Text File. Used in some security programs. | |
| ETW | Proprietary format from EnterTech for the MagicSing/Mic Karaoke product line. | Enter-Tech |
| ETX | Structure-enhanced text for some ascii text browsers | |
| EUI | Ensoniq EPS family CD image | AWAVE |
| EVT | Events descriptions | |
| EVY | Document | WordPerfect Envoy |
| EWD | Document | Express Publisher for Windows |
| EX3 | Device driveR | Harvard Graphics 3.0 |
| EXC | Exclude file for Optimize (do not process) (QEMM) | QEMM |
| EXC | REXX source code file | VM/CMS |
| EXE | Directly executable program | DOS |
| EXF | Excute file | OnHand PC |
| EXM | MSDOS executable, system-manager compliant (HP calculator) | HP calculator |
| EXP | Drawing File format | Drawing Express |
| EXP | Protected mode EXE by PharLap Software | PharLap |
| EXP | Exports Library File | VisualStudio |
| EXT | Extensions descriptions file | |
| EXX | Intermediate file by MsgPut | IBM LinkWay |
| EZF | Fax | Calculus EZ-Fax |
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