Discovery
Albert Hofmann, born in Baden, Switzerland, joined the pharmaceutical-chemical department of Sandoz Laboratories, located in Basel as a co-worker with professor Arthur Stoll, founder and director of the pharmaceutical department. He began studying the medicinal plant squill and the fungus ergot as part of a program to purify and synthesize active constituents for use as pharmaceuticals. His main contribution was to elucidate the chemical structure of the common nucleus of Scilla glycosides (an active principal of Mediterranean Squill). While researching lysergic acid derivatives, Hofmann first synthesized LSD on November 16, 1938. The main intention of the synthesis was to obtain a respiratory and circulatory stimulant (an analeptic). It was set aside for five years, until April 16, 1943, when Hofmann decided to take a second look at it. While re-synthesizing LSD, he accidentally absorbed a small amount of the drug through his fingertips and serendipitously discovered its powerful effects. He described what he felt as being:
... affected by a remarkable restlessness, combined with a slight dizziness. At home I lay down and sank into a not unpleasant intoxicated-like condition, characterized by an extremely stimulated imagination. In a dreamlike state, with eyes closed (I found the daylight to be unpleasantly glaring), I perceived an uninterrupted stream of fantastic pictures, extraordinary shapes with intense, kaleidoscopic play of colors. After some two hours this condition faded away.
Read more about this topic: History Of Lysergic Acid Diethylamide
Famous quotes containing the word discovery:
“That the discovery of this great truth, which lies so near and obvious to the mind, should be attained to by the reason of so very few, is a sad instance of the stupidity and inattention of men, who, though they are surrounded with such clear manifestations of the Deity, are yet so little affected by them, that they seem as it were blinded with excess of light.”
—George Berkeley (1685–1753)
“The new supplants the old. Yet men’s minds are stuffed with outworn bunk. Educating the young in the latest findings of authorities and scholars in the social sciences is important. It is equally important to devise ways and means for aiding the middle-aged and old to reexamine hang-over unscientific doctrines and ideas in the light of recent discovery and research.”
—Mary Barnett Gilson (1877–?)
“One of the laudable by-products of the Freudian quackery is the discovery that lying, in most cases, is involuntary and inevitable—that the liar can no more avoid it than he can avoid blinking his eyes when a light flashes or jumping when a bomb goes off behind him.”
—H.L. (Henry Lewis)